Abstract β-Lactam antibiotics are one of the most relevant drug classes of antibacterial
agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting
Gram-negative bacteria, predominantly affecting immunocompromised patients, but its …

Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …

Carbapenem‐resistant Enterobacteriaceae (CRE) have been listed by the WHO as high‐
priority pathogens owing to their high association with mortalities and morbidities …

Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

Carbapenems are a class of antimicrobial agents reserved for infections caused by
multidrug-resistant microorganisms. The emergence of carbapenem resistance has become …

The appearance of antibiotic drugs revolutionized the possibilities for treatment of diseases
with high mortality such as pneumonia, sepsis, plaque, diphtheria, tetanus, typhoid fever …

Urinary tract infections (UTIs) are some of the most common infections in human medicine
worldwide, recognized as an important public health concern to healthcare systems around …

β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …