Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones,
heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in …

Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

We investigated whether or not the topographic regulation of melanocyte differentiation is
determined by mesenchymal–epithelial interactions via fibroblast-derived factors. The …

The production of melanin pigments by melanocytes and their quantity, quality, and
distribution play a decisive role in determining human skin, eye, and hair color, and protect …

Abstract Background Long noncoding RNAs (lncRNAs) play roles in almost all biological
processes; however, their function and profile in skin development and pigmentation is less …

BACKGROUND AND OBJECTIVE: The biosafety of hydroquinone and its derivatives as skin
whitening agent remains controversial. Here, we investigated the effects of hydroquinone …

Chlorogenic acid (CGA), the ester formed between caffeic acid and l-quinic acid, is a
widespread phenolic compound. It is part of the human diet, found in foods such as coffee …

Within the hair follicle (HF) niche, dermal papilla (DP) cells are well known for the hair
induction capacity; however, DP cell signaling also regulates HF pigmentation. Here we …

We describe a mechanistic model whereby Foxd3, a forkhead transcription factor, prevents
neural crest-derived precursors from acquiring a melanophore fate. Foxd3 regulates this fate …