Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Reactive oxygen species (ROS) are essential for cellular signaling and response to stress.
The level of ROS and the type of ROS determine the ability of cells to undergo cell death …

Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

Mitochondria is one of the main source of oxidative stress (ROS), as it utilizes the oxygen for
the energy production. ROS and RNS are normally generated by tightly regulated enzymes …

Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …

Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …