[HTML][HTML] Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives
A Li, A Bouhss, MJ Clément, C Bauvais… - Frontiers in Molecular …, 2023 - frontiersin.org
In recent years, RNA has gained traction both as a therapeutic molecule and as a
therapeutic target in several human pathologies. In this review, we consider the approach of …
therapeutic target in several human pathologies. In this review, we consider the approach of …
Comprehensive pan-cancer analysis identifies the RNA-binding protein LRPPRC as a novel prognostic and immune biomarker
Z Wu, X Liu, F Xie, C Ma, EWF Lam, N Kang, D Jin… - Life Sciences, 2024 - Elsevier
Aims RNA-binding proteins (RBPs) play pivotal roles in carcinogenesis and immunotherapy.
Leucine-rich pentapeptide repeat-containing protein (LRPPRC) is crucial for RNA …
Leucine-rich pentapeptide repeat-containing protein (LRPPRC) is crucial for RNA …
[HTML][HTML] Targeting leucine-rich PPR motif-containing protein/LRPPRC by 5, 7, 4′-trimethoxyflavone suppresses esophageal squamous cell carcinoma progression
H Liu, Y Zhou, M Fredimoses, P Niu, Y Ge, R Wu… - International Journal of …, 2024 - Elsevier
Abstract JAK2/STAT3/MYC axis is dysregulated in nearly 70% of human cancers, but
targeting this pathway therapeutically remains a big challenge in cancer therapy. In this …
targeting this pathway therapeutically remains a big challenge in cancer therapy. In this …
[HTML][HTML] Stable Dual miR-143 and miR-506 Upregulation Inhibits Proliferation and Cell Cycle Progression
The mainstays of lung cancer pathogenesis are cell cycle progression dysregulation,
impaired apoptosis, and unregulated cell proliferation. While individual microRNA (miR) …
impaired apoptosis, and unregulated cell proliferation. While individual microRNA (miR) …
[HTML][HTML] Role of natural products in tumor therapy from basic research and clinical perspectives
Z Wang, Z Liu, J Qu, Y Sun, W Zhou - Acta Materia Medica, 2024 - scienceopen.com
Cancer is the leading cause of morbidity and mortality worldwide and is an important barrier
to lengthening life expectancy in every country. Natural products are receiving increased …
to lengthening life expectancy in every country. Natural products are receiving increased …