Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …

Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic
chemistry due to their widespread applications in drug discovery and development. MCRs …

Background The development of new effective microbicide surfactants and the search for the
structure–biological activity relationship is an important and promising problem. Surfactants …

Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …

Antimicrobial and cytotoxic activities of several ammonium derivatives of diterpenoids steviol
and isosteviol have been investigated in vitro. The results have showed that these …

Passerini three-component reactions (P-3CRs) based on isonitriles are impressive synthetic
protocols in which a number of starting materials react with each other to provide poly …

Recently, interest in matrix metalloproteinases (MMPs)-10 and-13 has been revitalized with
the growing knowledge on their relevance within the MMPs network and significance of their …

α-Acyloxy carboxamides are important multifunctional natural products that show bioactive
and pharmacological activities. Traditional three-component Passerini reactions among …

Background: The cancer is still a major cause of death worldwide. Among different targets to
design anticancer agents, caspase-3 is an important target as its cleavage and activation …