Positive and negative selection of T cells
TK Starr, SC Jameson… - Annual review of …, 2003 - annualreviews.org
A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …
that are major histocompatibility complex restricted but tolerant to self-antigens. This …
T-cell development and the CD4–CD8 lineage decision
RN Germain - Nature reviews immunology, 2002 - nature.com
Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
AE Moran, KL Holzapfel, Y Xing… - Journal of Experimental …, 2011 - rupress.org
The ability of antigen receptors to engage self-ligands with varying affinity is crucial for
lymphocyte development. To further explore this concept, we generated transgenic mice …
lymphocyte development. To further explore this concept, we generated transgenic mice …
Influence of inflammation in the process of T lymphocyte differentiation: proliferative, metabolic, and oxidative changes
T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last
stages of their differentiation, in a replicative state of senescence, go through a series of …
stages of their differentiation, in a replicative state of senescence, go through a series of …
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling
INTRODUCTION T cell receptor (TCR) recognition of peptide–major histocompatibility
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
Selecting and maintaining a diverse T-cell repertoire
AW Goldrath, MJ Bevan - Nature, 1999 - nature.com
To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …
system looks inward, using the variety of self-antigens to select and maintain a diverse …
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand
B Bielekova, B Goodwin, N Richert, I Cortese… - Nature medicine, 2000 - nature.com
Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple
sclerosis. The myelin basic protein peptide (aa 83–99) represents one candidate antigen; …
sclerosis. The myelin basic protein peptide (aa 83–99) represents one candidate antigen; …
Selection of self-reactive T cells in the thymus
GL Stritesky, SC Jameson… - Annual review of …, 2012 - annualreviews.org
On the whole, the healthy adaptive immune system is responsive to foreign antigens and
tolerant to self. However, many individual lymphocytes have, and even require, substantial …
tolerant to self. However, many individual lymphocytes have, and even require, substantial …
Naive T cell homeostasis: from awareness of space to a sense of place
K Takada, SC Jameson - Nature Reviews Immunology, 2009 - nature.com
The peripheral naive T cell pool is fairly stable in number, diversity and functional
competence in the absence of vigorous immune responses. However, this apparent …
competence in the absence of vigorous immune responses. However, this apparent …
Decision checkpoints in the thymus
AC Carpenter, R Bosselut - Nature immunology, 2010 - nature.com
The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …
events, during which hematopoietic precursors give rise to T cells ready to respond to …