A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …

Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …

The ability of antigen receptors to engage self-ligands with varying affinity is crucial for
lymphocyte development. To further explore this concept, we generated transgenic mice …

T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last
stages of their differentiation, in a replicative state of senescence, go through a series of …

INTRODUCTION T cell receptor (TCR) recognition of peptide–major histocompatibility
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …

To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …

Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple
sclerosis. The myelin basic protein peptide (aa 83–99) represents one candidate antigen; …

On the whole, the healthy adaptive immune system is responsive to foreign antigens and
tolerant to self. However, many individual lymphocytes have, and even require, substantial …

The peripheral naive T cell pool is fairly stable in number, diversity and functional
competence in the absence of vigorous immune responses. However, this apparent …

The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …