Glucocorticoid resistance in inflammatory diseases

PJ Barnes, IM Adcock - The Lancet, 2009 - thelancet.com
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and …

Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis

RB Sartor - Nature clinical practice Gastroenterology & hepatology, 2006 - nature.com
Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory
conditions that are immunologically mediated. Although their exact etiologies remain …

Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis

A Dignass, R Eliakim, F Magro, C Maaser… - Journal of Crohn's …, 2012 - academic.oup.com
Ulcerative colitis is a lifelong disease arising from an interaction between genetic and
environmental factors, observed predominantly in the developed countries of the world. The …

Treatment of inflammatory bowel disease (IBD)

AB Pithadia, S Jain - Pharmacological Reports, 2011 - Springer
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have …

Glucocorticosteroids: current and future directions

PJ Barnes - British journal of pharmacology, 2011 - Wiley Online Library
Glucocorticoids are the most effective anti‐inflammatory therapy for asthma yet are relatively
ineffective in chronic obstructive pulmonary disease. Glucocorticoids suppress inflammation …

Neuroendocrine regulation of immunity

JI Webster, L Tonelli… - Annual review of …, 2002 - annualreviews.org
A reciprocal regulation exists between the central nervous and immune systems through
which the CNS signals the immune system via hormonal and neuronal pathways and the …

The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression

K De Bosscher, W Vanden Berghe… - Endocrine …, 2003 - academic.oup.com
The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …

Glucocorticoid sensitivity in health and disease

RA Quax, L Manenschijn, JW Koper… - Nature Reviews …, 2013 - nature.com
Glucocorticoids regulate many physiological processes and have an essential role in the
systemic response to stress. For example, gene transcription is modulated by the …

Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression

D Turner, CM Walsh, AH Steinhart… - Clinical Gastroenterology …, 2007 - Elsevier
Background & Aims: Colectomy is a potentially life-saving procedure for patients with severe
attacks of UC who fail medical therapy. We aimed to systematically review studies that …

European evidence-based consensus on the diagnosis and management of ulcerative colitis: definitions and diagnosis

EF Stange, SPL Travis, S Vermeire… - Journal of Crohn's …, 2008 - academic.oup.com
Ulcerative colitis is a life long disease arising from an interaction between genetic and
environmental factors, but observed predominantly in the developed countries of the world …