Mononuclear non-heme Fe (II)-and 2-oxoglutarate (2OG)-dependent oxygenases comprise
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative …

Conspectus Non-heme iron dioxygenases catalyze vital processes for human health related
to the biosynthesis of essential products and the biodegradation of toxic metabolites. Often …

The naphthyridinomycin biosynthesis enzyme NapI selectively performs the desaturation of
a free l-arginine amino acid at the C4–C5 bond as part of its antibiotic biosynthesis reaction …

Enzymes are highly efficient catalysts in Nature that often react with high stereo-, chemo-,
and regioselectivity. Usually, enzymes achieve this selectivity through substrate binding and …

Aims Iron deficiency (ID) is associated with adverse outcomes in heart failure (HF) but the
underlying mechanisms are incompletely understood. Intracellular iron availability is …

Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …

The activation of dioxygen (O 2) by metalloenzymes proceeds by binding O 2 at their active
sites and then generating highly reactive, thermally unstable metal-oxygen intermediates …

Mononuclear iron‐containing enzymes are highly versatile oxidants that often react
stereospecifically and/or regioselectively with substrates. Combined experimental and …

Taurine/α‐ketoglutarate dioxygenase is an important enzyme that takes part in the cysteine
catabolism process in the human body and selectively hydroxylates taurine at the C1 …

Access to γ-functionalized amides represents a challenge in organic synthesis. The recent
upsurge of biomimetic metal nitrenoid-mediated C–H functionalization offers a method for …