DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …

Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …

Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are
characterized by distinct genetic and epigenetic alterations. Here we performed …

The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …

Pulmonary damage caused by chronic colonization of the cystic fibrosis (CF) lung by
microbial communities is the proximal cause of respiratory failure. While there has been an …

The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density
microarray for quantifying the methylation level of over 450 000 CpG sites within human …

The potential influence of underlying differences in relative leukocyte distributions in studies
involving blood-based profiling of DNA methylation is well recognized and has prompted …

Ionizing radiation is a known human carcinogen that can induce a variety of biological
effects depending on the physical nature, duration, doses and dose-rates of exposure …