Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components
of the inner layer of the joint capsule, referred to as the synovial membrane. They can be …

Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …

Since 2005, thousands of genome-wide association studies (GWAS) have been published,
identifying hundreds of thousands of genetic variants that increase risk of complex traits …

Objective Fibroblast-like synoviocytes (FLS) can augment the inflammatory process
observed in synovium of patients with rheumatoid arthritis (RA). A recent transcriptomic …

In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …

Bromodomain-and extra-terminal domain (BET) proteins are epigenetic reader proteins that
regulate transcription of their target genes by binding to acetylated histone side chains …

Liposomes show promise as biolubricants for damaged cartilage, but their small size results
in low joint and cartilage retention. We developed a zinc ion-based liposomal drug delivery …

The activation of stress response pathways in synovial fibroblasts (SF) is a hallmark of
rheumatoid arthritis (RA). CBP and p300 are two highly homologous histone acetyl …

Background Meta-analysis of genome-wide association studies (GWAS) data showed that
the relationship between hypothyroidism and rheumatoid arthritis (RA) risk remains under …

Three-dimensional (3D) genomics is an emerging field of research that investigates the
relationship between gene regulatory function and the spatial structure of chromatin …