Abstract Protein–protein interactions (PPIs), such as protein–protein inhibitor, antibody–
antigen complex, and supercomplexes play diverse and important roles in cells. Recent …

Extensive efforts have been directed at the discovery, investigation and clinical monitoring of
targeted therapeutics. These efforts may be facilitated by the convenient access of the …

Membrane proteins play crucial physiological roles in vivo and are the major category of
drug targets for pharmaceuticals. The research on membrane protein is a significant part in …

There is massive variation in intron numbers across eukaryotic genomes, yet the major
drivers of intron content during evolution remain elusive. Rapid intron loss and gain in some …

Sexual dimorphisms fuel significant intraspecific variation and evolutionary diversification.
Yet the developmental-genetic mechanisms underlying sex-specific development remain …

Drug repurposing (aka drug repositioning) is the search for new indications or molecular
targets distinct from a drug's putative activity, pharmacological effect or binding specificities …

Technological advances in high-throughput techniques have resulted in tremendous growth
of complex biological datasets providing evidence regarding various biomolecular …

Acute myeloid leukemia (AML) is a devastating disease characterized by poor patient
outcome and suboptimal chemotherapeutics. Here, a high-throughput screen identified …

Motivation: Many drugs interact with numerous proteins besides their intended therapeutic
targets and a substantial portion of these interactions is yet to be elucidated. Protein–Drug …

During metastasis, cancer cells transcend from primary site to normal cells area upon
attaining epithelial to mesenchymal transition (EMT) causing malignant cancer disease …