Insufficient sun exposure has become a real public health problem

L Alfredsson, BK Armstrong, DA Butterfield… - International Journal of …, 2020 - mdpi.com
This article aims to alert the medical community and public health authorities to
accumulating evidence on health benefits from sun exposure, which suggests that …

iNOS as a metabolic enzyme under stress conditions

S Anavi, O Tirosh - Free Radical Biology and Medicine, 2020 - Elsevier
Nitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different
biochemical processes. NO is synthesized from l-arginine through the action of the nitric …

Role of nitric oxide in regulating epidermal permeability barrier function

MQ Man, JS Wakefield, TM Mauro… - Experimental …, 2022 - Wiley Online Library
Nitric oxide (NO), a free radical molecule synthesized by nitric oxide synthases (NOS),
regulates multiple cellular functions in a variety of cell types. These NOS, including …

Aspalathin-enriched green rooibos extract reduces hepatic insulin resistance by modulating PI3K/AKT and AMPK pathways

SE Mazibuko-Mbeje, PV Dludla, C Roux… - International journal of …, 2019 - mdpi.com
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …

MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα

A Jaiswal, SS Reddy, M Maurya, P Maurya… - Cellular & molecular …, 2019 - nature.com
In human adipose tissue and obesity, miR-99a expression is negatively correlated with
inflammation. Therefore, the present study investigated the role of miR-99a in macrophage …

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

RP Ceddia, S Collins - Clinical science, 2020 - portlandpress.com
With the ever-increasing burden of obesity and Type 2 diabetes, it is generally
acknowledged that there remains a need for developing new therapeutics. One potential …

Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C

S Becerril, A Rodriguez, V Catalán… - International Journal of …, 2018 - nature.com
Abstract Background/Objectives: Obesity is related to a dynamic extracellular matrix (ECM)
remodeling, which involves the synthesis and degradation of different proteins, such as …

[HTML][HTML] Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice

AP Gupta, P Singh, R Garg, GR Valicherla… - Biomedicine & …, 2019 - Elsevier
Aims To investigate the role of pancreastatin inhibitor (PSTi8) in lipid homeostasis and
insulin sensitivity in dexamethasone induced fatty liver disease associated type 2 diabetes …

Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D

QL Quan, KN Yoon, JS Lee, EJ Kim… - Photodermatology …, 2023 - Wiley Online Library
Abstract Background/Purpose Ultraviolet (UV) radiation has both harmful and beneficial
effects on human skin and health. It causes skin damage, aging, and cancer; however, it is …

Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive mice

SS Reddy, H Agarwal, MK Barthwal - Journal of molecular and cellular …, 2018 - Elsevier
Abstract Cilostazol (Ciloz) a potent Type III phosphodiesterase inhibitor is effective against
inflammation, insulin resistance and cardiomyopathy. However, the effect of Ciloz on obesity …