Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

High‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein
involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 …

High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has
been widely reported to play a pivotal role in the pathogenesis of hematopoietic …

Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics,
cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic …

Responding to tissue injury, skeletal muscles undergo the tissue destruction and
reconstruction accompanied with inflammation. The immune system recognizes the …

High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription
regulation, DNA replication and repair and nucleosome assembly. HMGB1 is passively …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …