The interplay between genetic transformations, biochemical communications, and physical
interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related …

Matrigel is the most commonly used matrix for 3D organoid cultures. Research on the
biomaterial basis of Matrigel for organoid cultures is a highly challenging field. Currently …

Background Cancer cells remodel their local physical environment through processes of
matrix reorganisation, deposition, stiffening and degradation. Urokinase-type plasminogen …

Slowing peritoneal spread in high-grade serous ovarian cancer (HGSOC) would improve
patient prognosis and quality of life. HGSOC spreads when single cells and spheroids …

Stromal cells are key components of the tumour microenvironment (TME) and their
incorporation into 3D engineered tumour-stroma models is essential for tumour mimicry. By …

Epithelial to mesenchymal transition (EMT) in cancer is the process described where cancer
epithelial cells acquire mesenchymal properties which can lead to enhanced invasiveness …

Aims: Renal tissue is a dynamic biophysical microenvironment, regulating healthy function
and influencing tumor development. Matrix remodelling is an iterative process and aberrant …

Cancer-associated fibroblasts (CAFs) play a major role in reorganizing the physical tumor
micro-environment and changing tissue stiffness. Herein, using an engineered three …

Despite clinical advances, the development of anticancer drugs faces high failure rates
owing to cancer drug resistance and insufficient understanding of the native tumor …

Vascularization is driven by morphogen signals and mechanical cues that coordinately
regulate cellular force generation, migration, and shape change to sculpt the developing …