The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal
epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the …

Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

Among all adult somatic stem cells, those of the corneal epithelium are unique in their
exclusive location in a defined limbal structure termed Palisades of Vogt. As a result …

Ex vivo cultured limbal epithelial stem cells have been used successfully to treat corneal
limbal stem cell deficiency. We identified 17 reports of the application of this novel cell …

Purpose This study aimed to uncover novel cell types in heterogenous basal limbus of
human cornea for identifying LSC at single cell resolution. Methods Single cells of human …

Purpose: Human limbal palisade of Vogt is an ideal model for studying and practicing
regenerative medicine due to their accessibility. Nonresolving inflammation is a common …

Cryopreserved amniotic membrane modulates adult wound healing by promoting
epithelialization while suppressing stromal inflammation, angiogenesis and scarring. Such …

Stem cells have several unique attributes, the key features being their potency and plasticity.
They have the ability to give rise to multiple cell lineages and to transdifferentiate into totally …

Purpose.: Total bilateral corneal limbal epithelial stem cell deficiency (LSCD) cannot be
treated with the surgical transplantation of autologous limbus or cultured autologous limbal …