Pathogenicity and virulence of Clostridioides difficile

JE Buddle, RP Fagan - Virulence, 2023 - Taylor & Francis
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Monoclonal antibodies as an antibacterial approach against bacterial pathogens

DV Zurawski, MK McLendon - Antibiotics, 2020 - mdpi.com
In the beginning of the 21st century, the frequency of antimicrobial resistance (AMR) has
reached an apex, where even 4th and 5th generation antibiotics are becoming useless in …

Clostridioides difficile infection in children: Recent updates on epidemiology, diagnosis, therapy

DA Shirley, W Tornel, CA Warren, S Moonah - Pediatrics, 2023 - publications.aap.org
Clostridioides (formerly Clostridium) difficile is the most important infectious cause of
antibiotic-associated diarrhea worldwide and a leading cause of healthcare-associated …

A probiotic yeast-based immunotherapy against Clostridioides difficile infection

K Chen, Y Zhu, Y Zhang, T Hamza, H Yu… - Science translational …, 2020 - science.org
Antibiotic-resistant Clostridioides difficile is an anaerobic Gram-positive bacterium that
colonizes the colon and is responsible for more than 29,000 deaths in the United States …

Advances in the diagnosis and treatment of Clostridium difficile infections

Z Peng, L Ling, CW Stratton, C Li… - Emerging microbes & …, 2018 - Taylor & Francis
Clostridium difficile is a leading cause of antibiotic-associated diarrhea worldwide. The
diagnosis of C. difficile infection (CDI) requires both clinical manifestations and a positive …

Encapsulation protocol for fecal microbiota transplantation

D Sipos, A Varga, Á Kappéter, B Halda-Kiss… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Clostridioides difficile infections (CDI) continue to pose a challenge for
clinicians. Fecal microbiota transplantation (FMT) is an effective treatment option in CDI …

Development and validation of a prediction model for mortality and adverse outcomes among patients with peripheral eosinopenia on admission for Clostridium …

AS Kulaylat, EL Buonomo, KW Scully… - JAMA …, 2018 - jamanetwork.com
Importance Recent evidence from an animal model suggests that peripheral loss of
eosinophils inClostridium difficileinfection (CDI) is associated with severe disease. The …

Bezlotoxumab: an emerging monoclonal antibody therapy for prevention of recurrent Clostridium difficile infection

BD Navalkele, T Chopra - Biologics: Targets and Therapy, 2018 - Taylor & Francis
Clostridium difficile infection (CDI) is the most common health care-acquired infection
associated with high hospital expenditures. The incidence of subsequent recurrent CDI …

Synthesis of recovery patterns in microbial communities across environments

SD Jurburg, SA Blowes, A Shade, N Eisenhauer… - Microbiome, 2024 - Springer
Background Disturbances alter the diversity and composition of microbial communities. Yet
a generalized empirical assessment of microbiome responses to disturbance across …

New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation

T Bratkovič, A Zahirović, M Bizjak, M Rupnik… - Gut …, 2024 - Taylor & Francis
Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It
is particularly problematic as a hospital-acquired infection, causing significant costs to the …