[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer

D Müller, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer

WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

[HTML][HTML] Colorectal cancer: from prevention to personalized medicine

G Binefa, F Rodríguez-Moranta, À Teule… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a very heterogeneous disease that is caused by the interaction
of genetic and environmental factors. CRC develops through a gradual accumulation of …

DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Surveillance after curative treatment for colorectal cancer

EP van der Stok, MCW Spaander… - Nature reviews Clinical …, 2017 - nature.com
Treatments for colorectal cancer (CRC) of all stages have evolved considerably over the
past two decades, resulting in improved long-term outcomes. After curative treatment …

Cell-free DNA in the blood as a solid tumor biomarker—a critical appraisal of the literature

K Jung, M Fleischhacker, A Rabien - Clinica chimica acta, 2010 - Elsevier
Circulating cell-free DNA (cfDNA) has been suggested as a cancer biomarker. Several
studies assessed the usefulness of quantitative and qualitative tumor-specific alterations of …

Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay

R Grützmann, B Molnar, C Pilarsky, JK Habermann… - PloS one, 2008 - journals.plos.org
Background Colorectal cancer (CRC) is the second leading cause of cancer deaths despite
the fact that detection of this cancer in early stages results in over 90% survival rate …

DNA methylation markers in colorectal cancer

MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer

JMK Ng, J Yu - International journal of molecular sciences, 2015 - mdpi.com
Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …