The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …

Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …

Objective This study aimed to elucidate the presence, antigen specificities, and potential
clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …

Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …

The epithelial–mesenchymal transition (EMT) program is crucial for transforming carcinoma
cells into a partially mesenchymal state, enhancing their chemoresistance, migration, and …

Sialic acids and heparan sulfates make up the outermost part of the cell membrane and the
extracellular matrix. Both structures are characterized by being negatively charged, serving …

Proteoglycans (PGs), a class of carbohydrate-modified proteins, are present in essentially all
metazoan organisms investigated to date. PGs are composed of glycosaminoglycan (GAG) …