[HTML][HTML] Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
[HTML][HTML] Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …
The glycosaminoglycan interactome 2.0
SD Vallet, C Berthollier… - American Journal of …, 2022 - journals.physiology.org
Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …
Anti–neutrophil extracellular trap antibodies in antiphospholipid antibody–positive patients: results from the antiphospholipid syndrome alliance for clinical trials and …
Objective This study aimed to elucidate the presence, antigen specificities, and potential
clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a …
clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a …
Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials
J Le Pennec, C Picart, RR Vivès… - Advanced …, 2024 - Wiley Online Library
Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease
Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …
expressed on the cell surface and in the extracellular matrix of all animal cells. These …
A biological guide to glycosaminoglycans: current perspectives and pending questions
S Ricard‐Blum, RR Vivès, L Schaefer… - The FEBS …, 2024 - Wiley Online Library
Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …
The exostosin glycosyltransferase 1/STAT3 axis is a driver of breast cancer aggressiveness
The epithelial–mesenchymal transition (EMT) program is crucial for transforming carcinoma
cells into a partially mesenchymal state, enhancing their chemoresistance, migration, and …
cells into a partially mesenchymal state, enhancing their chemoresistance, migration, and …
[HTML][HTML] Heparan sulfate and sialic acid in viral attachment: Two sides of the same coin?
IE Ramos-Martínez, E Ramos-Martínez… - International Journal of …, 2022 - mdpi.com
Sialic acids and heparan sulfates make up the outermost part of the cell membrane and the
extracellular matrix. Both structures are characterized by being negatively charged, serving …
extracellular matrix. Both structures are characterized by being negatively charged, serving …
[HTML][HTML] Site-specific glycosylation of proteoglycans: A revisited frontier in proteoglycan research
F Noborn, J Nilsson, G Larson - Matrix Biology, 2022 - Elsevier
Proteoglycans (PGs), a class of carbohydrate-modified proteins, are present in essentially all
metazoan organisms investigated to date. PGs are composed of glycosaminoglycan (GAG) …
metazoan organisms investigated to date. PGs are composed of glycosaminoglycan (GAG) …