Annexin A1 as a regulator of immune response in cancer

TG Araújo, STS Mota, HSV Ferreira, MA Ribeiro… - Cells, 2021 - mdpi.com
Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

From NSAIDs to glucocorticoids and beyond

A Sinniah, S Yazid, RJ Flower - Cells, 2021 - mdpi.com
Our interest in inflammation and its treatment stems from ancient times. Hippocrates used
willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative …

Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer's disease

PK Jayaswamy, M Vijaykrishnaraj, P Patil… - Ageing Research …, 2023 - Elsevier
Epidermal growth factor receptor (EGFR) plays a pivotal role in early brain development,
although its expression pattern declines in accordance with the maturation of the active …

Knockdown of annexin-A1 inhibits growth, migration and invasion of glioma cells by suppressing the PI3K/Akt signaling pathway

L Wei, L Li, L Liu, R Yu, X Li, Z Luo - ASN neuro, 2021 - journals.sagepub.com
ANXA1, which can bind phospholipid in a calcium dependent manner, is reported to play a
pivotal role in tumor progression. However, the role and mechanism of ANXA1 involved in …

Analysis of the expression and prognostic value of annexin family proteins in bladder cancer

WB Wu, GZ Jia, L Chen, HT Liu, SJ Xia - Frontiers in genetics, 2021 - frontiersin.org
Background Bladder cancer (BC) is the most common tumor of the urinary system. Non-
muscle-invasive bladder cancer (NMIBC) has a high recurrence rate after surgery, and …

Zooming into the dark side of human annexin-S100 complexes: dynamic alliance of flexible partners

J Weisz, VN Uversky - International journal of molecular sciences, 2020 - mdpi.com
Annexins and S100 proteins form two large families of Ca2+-binding proteins. They are
quite different both structurally and functionally, with S100 proteins being small (10–12 kDa) …

Annexin A1 mimetic peptide and piperlongumine: anti-inflammatory profiles in endotoxin-induced uveitis

AP Girol, C de Freitas Zanon, ÍP Caruso… - Cells, 2021 - mdpi.com
Uveitis is one of the main causes of blindness worldwide, and therapeutic alternatives are
worthy of study. We investigated the effects of piperlongumine (PL) and/or annexin A1 …

Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis

EE Herrera-López, D Guerrero-Escalera… - Scientific Reports, 2023 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late diagnosis; therefore,
the identification of new early biomarkers could help reduce mortality. We determine the …

Electrical stimulation of the auricular branch vagus nerve using random and alternating frequencies triggers a rapid onset and pronounced antihyperalgesia via …

DC Salm, VV Horewicz, F Tanaka, JK Ferreira… - Molecular …, 2023 - Springer
This study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous
vagus nerve electrical stimulation (pVNS) by comparing the effects of alternating and …

HDX-MS for epitope characterization of a therapeutic ANTIBODY candidate on the calcium-binding protein annexin-A1

M Gramlich, HCW Hays, S Crichton, PD Kaiser… - Antibodies, 2021 - mdpi.com
Annexin-A1 (ANXA1) belongs to a class of highly homologous Ca2+-dependent
phospholipid-binding proteins. Its structure consists of a core region composed of four …