Detection of toxins involved in foodborne diseases caused by Gram‐positive bacteria
Bacterial toxins are food safety hazards causing about 10% of all reported foodborne
outbreaks in Europe. Pertinent to Gram‐positive pathogens, the most relevant toxins are …
outbreaks in Europe. Pertinent to Gram‐positive pathogens, the most relevant toxins are …
Rapid detection of botulinum neurotoxins—A review
A toxin is a poisonous substance produced within living cells or organisms. One of the most
potent groups of toxins currently known are the Botulinum Neurotoxins (BoNTs). These are …
potent groups of toxins currently known are the Botulinum Neurotoxins (BoNTs). These are …
A novel botulinum neurotoxin, previously reported as serotype H, has a hybrid-like structure with regions of similarity to the structures of serotypes A and F and is …
SE Maslanka, C Lúquez, JK Dykes… - The Journal of …, 2016 - academic.oup.com
Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin
(BoNT) on nerve cells. There are 7 known serotypes (A–G) of BoNT and up to 40 genetic …
(BoNT) on nerve cells. There are 7 known serotypes (A–G) of BoNT and up to 40 genetic …
Impedimetric immunosensor for the label-free and direct detection of botulinum neurotoxin serotype A using Au nanoparticles/graphene-chitosan composite
In this work, a novel nanocomposite film consisting of the Au nanoparticles/graphene-
chitosan has been designed to construct an impedimetric immunosensor for a rapid and …
chitosan has been designed to construct an impedimetric immunosensor for a rapid and …
Characterization of Botulinum Neurotoxin A Subtypes 1 Through 5 by Investigation of Activities in Mice, in Neuronal Cell Cultures, and In Vitro
RCM Whitemarsh, WH Tepp, M Bradshaw… - Infection and …, 2013 - Am Soc Microbiol
Botulinum neurotoxins (BoNTs) are synthesized by Clostridium botulinum and exist as
seven immunologically distinct serotypes designated A through G. For most serotypes …
seven immunologically distinct serotypes designated A through G. For most serotypes …
Botulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassay
E Fernandez-Salas, J Wang, Y Molina, JB Nelson… - PLoS …, 2012 - journals.plos.org
Botulinum neurotoxin serotype A (BoNT/A), a potent therapeutic used to treat various
disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development …
disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development …
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection
RCM Whitemarsh, MJ Strathman… - Toxicological …, 2012 - academic.oup.com
Human induced pluripotent stem cells (hiPSC) hold great promise for providing various
differentiated cell models for in vitro toxigenicity testing. For Clostridium botulinum …
differentiated cell models for in vitro toxigenicity testing. For Clostridium botulinum …
Progress in cell based assays for botulinum neurotoxin detection
S Pellett - Botulinum neurotoxins, 2013 - Springer
Botulinum neurotoxins (BoNTs) are the most potent human toxins known and the causative
agent of botulism, and are widely used as valuable pharmaceuticals. The BoNTs are …
agent of botulism, and are widely used as valuable pharmaceuticals. The BoNTs are …
The light chain defines the duration of action of botulinum toxin serotype A subtypes
S Pellett, M Bradshaw, WH Tepp, CL Pier… - MBio, 2018 - Am Soc Microbiol
Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used
pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins …
pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins …
[HTML][HTML] Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1
CL Pier, C Chen, WH Tepp, G Lin, KD Janda… - FEBS letters, 2011 - Elsevier
Botulinum neurotoxins (BoNTs), the causative agent of human botulism, are the most potent
naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an …
naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an …