Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic
activity toward a plethora of clinically important medications. Thus, single nucleotide variants …

Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …

Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to
study using current in vitro models such as primary human hepatocyte (PHH) monolayer …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …

Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …