Simple Summary Splicing is an important mechanism by which precursor mRNA is modified
into mature mRNA. This splicing plays a major role in the generation of different proteins …

Recent advances in drug development have seen numerous successful clinical translations
using synthetic antisense oligonucleotides (ASOs). However, major obstacles, such as …

The synthesis and incorporation of a tosylated phosphoramidite linker containing a disulfide
bond is described. Incorporation of the linker into short DNA and RNA oligomers proceeded …

We designed and synthesized a series of 2′-deoxyribonucleoside triphosphates (dNTPs)
bearing various lipid moieties. Fatty acid-and cholesterol-modified dNTPs proved to be …

We have found that antisense oligonucleotides and siRNA molecules modified with repeat
structures of disulfide units can be directly introduced into the cytoplasm and exhibit a …

Cancer is one of the leading causes of death globally. Epidermal growth factor receptor is
one of the proteins involved in cancer cell proliferation, differentiation, and invasion …

2′-O-Methyl (2′-OMe) antisense oligonucleotides (AOs) possessing a various number of
4-(trimethylammonio) butylsulfonyl or tosyl phosphoramidates (N+ and Ts-modifications …

Therapeutic oligonucleotides, such as antisense DNA, show promise in treating previously
untreatable diseases. However, their applications are still hindered by the poor membrane …

The nucleotide monomer containing the 1-phenyl-1, 2, 3-triazole group attached to the 5-
position of 2′-O-methyluridine is hereby presented together with a derivative further …

We used native chemical ligation (NCL) to synthesize a 2′-O-{N-[N-(S-tert-
butylthiocysteinyl) aminobutyl] carbamoylethyl}(CysBCE) ribothymidine-derived …