[HTML][HTML] PROTAC targeted protein degraders: the past is prologue

M Békés, DR Langley, CM Crews - Nature Reviews Drug Discovery, 2022 - nature.com
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …

Proximity-based modalities for biology and medicine

X Liu, A Ciulli - ACS Central Science, 2023 - ACS Publications
Molecular proximity orchestrates biological function, and blocking existing proximities is an
established therapeutic strategy. By contrast, strengthening or creating neoproximity with …

[HTML][HTML] Molecular regulation of plant responses to environmental temperatures

Y Ding, Y Shi, S Yang - Molecular plant, 2020 - cell.com
Temperature is a key factor governing the growth and development, distribution, and
seasonal behavior of plants. The entire plant life cycle is affected by environmental …

Multiple levels of crosstalk in hormone networks regulating plant defense

N Aerts, M Pereira Mendes… - The Plant Journal, 2021 - Wiley Online Library
Plant hormones are essential for regulating the interactions between plants and their
complex biotic and abiotic environments. Each hormone initiates a specific molecular …

[HTML][HTML] Jasmonic acid signaling pathway in plants

J Ruan, Y Zhou, M Zhou, J Yan, M Khurshid… - International journal of …, 2019 - mdpi.com
Jasmonic acid (JA) and its precursors and dervatives, referred as jasmonates (JAs) are
important molecules in the regulation of many physiological processes in plant growth and …

Role of jasmonic acid in plants: the molecular point of view

M Ghorbel, F Brini, A Sharma, M Landi - Plant Cell Reports, 2021 - Springer
Key message Recent updates in JA biosynthesis, signaling pathways and the crosstalk
between JA and others phytohormones in relation with plant responses to different stresses …

[HTML][HTML] Plant disease resistance-related signaling pathways: recent progress and future prospects

LN Ding, YT Li, YZ Wu, T Li, R Geng, J Cao… - International Journal of …, 2022 - mdpi.com
Plant–pathogen interactions induce a signal transmission series that stimulates the plant's
host defense system against pathogens and this, in turn, leads to disease resistance …

[HTML][HTML] Signaling crosstalk between salicylic acid and ethylene/jasmonate in plant defense: do we understand what they are whispering?

N Li, X Han, D Feng, D Yuan, LJ Huang - International journal of …, 2019 - mdpi.com
During their lifetime, plants encounter numerous biotic and abiotic stresses with diverse
modes of attack. Phytohormones, including salicylic acid (SA), ethylene (ET), jasmonate …

[HTML][HTML] Plant hormone signaling crosstalks between biotic and abiotic stress responses

YS Ku, M Sintaha, MY Cheung, HM Lam - International journal of …, 2018 - mdpi.com
In the natural environment, plants are often bombarded by a combination of abiotic (such as
drought, salt, heat or cold) and biotic (necrotrophic and biotrophic pathogens) stresses …

Leaf senescence: systems and dynamics aspects

HR Woo, HJ Kim, PO Lim… - Annual review of plant …, 2019 - annualreviews.org
Leaf senescence is an important developmental process involving orderly disassembly of
macromolecules for relocating nutrients from leaves to other organs and is critical for plants' …