AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Our understanding of the pathogenesis of diseases has advanced enormously in recent
decades. As a consequence, drug discovery has gradually shifted from an entirely …

The multifunctional nature of Alzheimer's disease calls for MTDLs (multitarget-directed
ligands) to act on different components of the pathology, like the cholinergic dysfunction and …

Acetylcholinesterase (AChE) is popularly used in biological and chemical sensors since it
can be inhibited or reactivated. As the inhibitor of AChE is meaningful for many …

Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …

Cholinesterases are important biological targets responsible for regulation of cholinergic
transmission, and their inhibitors are used for the treatment of Alzheimer's disease. To …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

By using fragments endowed with interesting and complementary properties for the
treatment of Alzheimer's disease (AD), a new family of tacrine–4-oxo-4 H-chromene hybrids …

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit
cholinesterases and decrease β-amyloid (Aβ) levels by complexation of redox-active metals …

The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …