Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

The development of precise connectivity patterns during the establishment of the nervous
system depends on the regulated action of diverse, conserved families of guidance cues …

During the development of the nervous system, neurons respond to the coordinated action
of a variety of attractive and repulsive signals from the embryonic environment. Netrins form …

Modulating protein–protein interactions involved in disease pathways is an attractive
strategy for developing drugs, but remains a challenge to achieve. One approach is to target …

The postsynaptic specialisation at glutamatergic synapses is composed of a network of
proteins located within the membrane and the underlying postsynaptic density. The strong …

Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …

Protein kinase A (PKA) exerts a profound influence on axon extension during development
and regeneration; however, the molecular mechanisms underlying these effects of PKA are …

Mutations in the parkin gene result in an autosomal recessive juvenile-onset form of
Parkinson's disease. As an E3 ubiquitin-ligase, parkin promotes the attachment of ubiquitin …