The gene ontology knowledgebase in 2023

SA Aleksander, J Balhoff, S Carbon, JM Cherry… - Genetics, 2023 - academic.oup.com
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …

Optimization of metabolomic data processing using NOREVA

J Fu, Y Zhang, Y Wang, H Zhang, J Liu, J Tang… - Nature protocols, 2022 - nature.com
A typical output of a metabolomic experiment is a peak table corresponding to the intensity
of measured signals. Peak table processing, an essential procedure in metabolomics, is …

KEGG for taxonomy-based analysis of pathways and genomes

M Kanehisa, M Furumichi, Y Sato… - Nucleic acids …, 2023 - academic.oup.com
Abstract KEGG (https://www. kegg. jp) is a manually curated database resource integrating
various biological objects categorized into systems, genomic, chemical and health …

Introducing the bacterial and viral bioinformatics resource center (BV-BRC): a resource combining PATRIC, IRD and ViPR

RD Olson, R Assaf, T Brettin, N Conrad… - Nucleic acids …, 2023 - academic.oup.com
Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the
Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the …

RCSB Protein Data Bank (RCSB. org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from …

SK Burley, C Bhikadiya, C Bi, S Bittrich… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …

[PDF][PDF] The gene ontology knowledgebase in 2023

D Ebert, M Feuermann, P Gaudet, NL Harris, DP Hill… - Genetics, 2023 - crick.figshare.com
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …

TTD: Therapeutic Target Database describing target druggability information

Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles

JA Castro-Mondragon, R Riudavets-Puig… - Nucleic acids …, 2022 - academic.oup.com
Abstract JASPAR (http://jaspar. genereg. net/) is an open-access database containing
manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six …

The carbohydrate-active enzyme database: functions and literature

E Drula, ML Garron, S Dogan, V Lombard… - Nucleic acids …, 2022 - academic.oup.com
Thirty years have elapsed since the emergence of the classification of carbohydrate-active
enzymes in sequence-based families that became the CAZy database over 20 years ago …

Enzyme function prediction using contrastive learning

T Yu, H Cui, JC Li, Y Luo, G Jiang, H Zhao - Science, 2023 - science.org
Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …