Reproducibility and reusability of the results of data-based modeling studies are essential.
Yet, there has been—so far—no broadly supported format for the specification of parameter …

Mathematical models of metabolic networks utilize simulation to study system-level
mechanisms and functions. Various approaches have been used to model the steady state …

For many biological systems, a variety of simulation models exist. A new simulation model is
rarely developed from scratch, but rather revises and extends an existing one. A key …

Computational modeling has become an established technique to encode mathematical
representations of cellular processes and gain mechanistic insights that drive testable …

An overwhelming majority of mathematical models of regulatory pathways, including the
intensively studied NF-κ B pathway, remains non-identifiable, meaning that their parameters …

The mammalian cell cycle is regulated by a well-studied but complex biochemical reaction
system. Computational models provide a particularly systematic and systemic description of …

Mathematical models of metabolic networks utilize simulation to study system-level
mechanisms and functions. Various approaches have been used to model the steady state …