Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Brown adipose tissue (BAT) activity contributes to cardiovascular health by its energy-
dissipating capacity but how BAT modulates vascular function and atherosclerosis through …

Myeloid-derived growth factor (MYDGF) is a paracrine protein produced by bone marrow-
derived monocytes and macrophages. Current research shows that it has protective effects …

Podocytes are unique, highly specialized, terminally differentiated cells, which are restricted
in a post-mitotic state with limited ability to repair or regenerate. Re-entering the mitotic …

Objective Diabetic kidney disease (DKD) is characterized by the abnormal deposition of
oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an …

Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …

BACKGROUND: Inflammation contributes to the pathogenesis of atherosclerosis. But little is
known about the potential benefits of inflammatory cells to atherosclerosis. The aim of this …

Restenosis after angioplasty is caused usually by neointima formation characterized by
aberrant vascular smooth muscle cell (VSMC) dedifferentiation. Myeloid-derived growth …

Clinicians have long been interested in understanding the molecular basis of diabetic
kidney disease (DKD) and its potential treatment targets. Its pathophysiology involves …

Background and aims Mesenchymal stromal cells (MSCs) a potentially effective disease-
modulating therapy for diabetic nephropathy (DN) but their clinical translation has been …