About forty percent of newly developed drugs are rejected by the pharmaceutical industry
and will never benefit a patient because of poor bioavailability due to low water solubility …

In 2008, we overviewed1 poly (amido amine) s, polypropylenimines, and related dendrimers
and dendrons possessing diverse 1 f 2 branching patterns that were predominately made …

The purpose of this analysis is to establish a quantitative structure–property relationship
(QSPR) between eV and ve-degree based topological descriptors and measured …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Camptothecin (CAM), a plant alkaloid and a potent antitumor agent, has a limited
therapeutic utility because of its poor aqueous solubility, lactone ring instability and serious …

A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and
succinic acid, is described for the encapsulation of the antitumor camptothecins, 10 …

Nanosponges (NSs) are a new age branched cyclodextrin (CD) polymeric systems
exhibiting tremendous potential in pharmaceutical, agro science, and biomedical …

Individualized medicine is the healthcare strategy that rebukes the idiomatic dogma of
'losing sight of the forest for the trees'. We are entering a new era of healthcare where it is no …

A novel method of delivering non-ionic, poorly water-soluble drugs such as campthothecin
was developed. Camptothecin was first incorporated into micelles derived from negatively …

Aim: Camptothecin is an anticancer drug that acts against a broad spectrum of tumors. The
clinical application of camptothecin is limited by its insolubility, instability, and toxicity …