Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Apolipoprotein AI (ApoA-I), the major protein component of high-density lipoproteins (HDL)
is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune …

Introduction Exosomes are closed-membrane nanovesicles that are secreted by a variety of
cells and exist in most body fluids. Recent studies have demonstrated the potential of …

Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Nephrotic syndrome results in hyperlipidemia and profound alterations in lipid and
lipoprotein metabolism. Serum cholesterol, triglycerides, apolipoprotein B (apoB) …

The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

Since the discovery of the existence of superassemblies between mitochondrial respiratory
complexes, such superassemblies have been the object of a passionate debate. It is …

High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with
many minor proteins and lipids that influence the function of HDL. Although HDL is a …