The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

Apoptosis is often accompanied by degradation of chromosomal DNA. CAD, caspase-
activated DNase, was identified in 1998 as a DNase that is responsible for this process. In …

The relatively common occurrence of sequences within proteins that match the consensus
substrate specificity of caspases in intracellular proteins suggests a multitude of substrates …

▪ Abstract Most mammalian cells have nuclei that contain DNA, which replicates during cell
proliferation. DNA is destroyed by various developmental processes in mammals. It is …

Apoptosis plays a central role in the development and homeostasis of metazoans. Research
in the past two decades has led to the identification of hundreds of genes that govern the …

Maximal activation of NADPH oxidase requires formation of a complex between the p40
phox and p67 phox subunits via association of their PB1 domains. We have determined the …

The plant-type ferredoxins (Fds) are the [2Fe–2S] proteins that function primarily in
photosynthesis; they transfer electrons from photoreduced Photosystem I to ferredoxin …

Plants are an invaluable source of potential new anti‐cancer drugs. Momordica charantia is
one of these plants with both edible and medical value and reported to exhibit anticancer …

The sequential generation of large-scale DNA fragments followed by internucleosomal
chromatin fragmentation is a biochemical hallmark of apoptosis. One of the nucleases …

Immunity proteins are high affinity inhibitors of colicins–SOS-induced toxins released by
bacteria during times of stress. Recent work has shown that nuclease-specific immunity …