The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

In recent years, neonicotinoids have been the fastest‐growing class of insecticides in
modern crop protection, with widespread use against a broad spectrum of sucking and …

In recent years, neonicotinoid insecticides have been the fastest growing class of
insecticides in modern crop protection, with widespread use against a broad spectrum of …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Upon ligand binding at the subunit interfaces, the extracellular domain of the nicotinic
acetylcholine receptor undergoes conformational changes, and agonist binding …

Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …