Serotonergic neuromodulation contributes to enhanced voluntary muscle activation.
However, it is not known how the likely motoneurone receptor candidate (5‐HT2) influences …

Serotonin (5-HT) is a neuromodulator that is critical for regulating the excitability of spinal
motoneurons and the generation of muscle torque. However, the role of 5-HT in modulating …

Animal models indicate that serotonin (5-HT) release onto motoneurons facilitates motor
output, particularly during strong motor activities. However, evidence for 5-HT effects during …

Serotonin modulates corticospinal excitability, motoneurone firing rates and contractile
strength via 5‐HT2 receptors. However, the effects of these receptors on cortical and …

Cyproheptadine, a serotonin antagonist, has recently been reported to function as a novel
therapeutic agent by inhibiting PI3K/AKT signaling in several human cancers. However, the …

The histone methyltransferase SET7/9 methylates not only histone but also non‐histone
proteins as substrates, and therefore, SET7/9 inhibitors are considered candidates for the …

The centrally acting muscle relaxant cyclobenzaprine decreases the amplitude of
monosynaptic reflex potentials by inhibiting the facilitatory descending serotonergic …

HT2 receptors on motoneurones play a critical role in facilitating persistent inward currents
(PICs). Although facilitation of PICs can enhance self‐sustained firing after periods of …

The McMurry coupling reaction has been recognized as one of the most efficient methods for
the synthesis of alkenes from carbonyl compounds. This reaction can be applied to the …

Set7/9 is a histone lysine methyltransferase, but it is also thought to be involved in a wide
variety of pathophysiological functions. We previously identified cyproheptadine, which has …