Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

Peroxisomes are ubiquitous organelles that house various metabolic reactions and are
essential for human health,,–. Luminal peroxisomal proteins are imported from the cytosol by …

Peroxisomes are highly metabolic, autonomously replicating organelles that generate
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …

Lipid droplets are organelles conserved across eukaryotes that store and release neutral
lipids to regulate energy homeostasis. In oilseed plants, fats stored in seed lipid droplets …

Posttranslational modification of proteins by acetylation and phosphorylation regulates most
cellular processes in living organisms. Surprisingly, the evolutionary conservation of …

The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …

Post-translational protein modifications initiate, regulate, propagate and terminate a wide
variety of processes in cells, and in particular, ubiquitylation targets substrate proteins for …