Cellular functions and molecular mechanisms of non-lysine ubiquitination
AJ McClellan, SH Laugesen, L Ellgaard - Open Biology, 2019 - royalsocietypublishing.org
Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …
The Ubiquitin–Proteasome System of Saccharomyces cerevisiae
Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel
Peroxisomes are ubiquitous organelles that house various metabolic reactions and are
essential for human health,,–. Luminal peroxisomal proteins are imported from the cytosol by …
essential for human health,,–. Luminal peroxisomal proteins are imported from the cytosol by …
ATM functions at the peroxisome to induce pexophagy in response to ROS
Peroxisomes are highly metabolic, autonomously replicating organelles that generate
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …
MHC class I antigen presentation: learning from viral evasion strategies
TH Hansen, M Bouvier - Nature Reviews Immunology, 2009 - nature.com
The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …
host with an important surveillance mechanism to protect against invading pathogens …
Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases
DS Jo, NY Park, DH Cho - Experimental & molecular medicine, 2020 - nature.com
In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …
become increasingly important. Together with the mitochondria and other cellular …
The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization
Lipid droplets are organelles conserved across eukaryotes that store and release neutral
lipids to regulate energy homeostasis. In oilseed plants, fats stored in seed lipid droplets …
lipids to regulate energy homeostasis. In oilseed plants, fats stored in seed lipid droplets …
Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation
BT Weinert, SA Wagner, H Horn, P Henriksen… - Science …, 2011 - science.org
Posttranslational modification of proteins by acetylation and phosphorylation regulates most
cellular processes in living organisms. Surprisingly, the evolutionary conservation of …
cellular processes in living organisms. Surprisingly, the evolutionary conservation of …
Non-lysine ubiquitylation: Doing things differently
IR Kelsall - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
[HTML][HTML] Non-canonical ubiquitylation: mechanisms and consequences
GS McDowell, A Philpott - The international journal of biochemistry & cell …, 2013 - Elsevier
Post-translational protein modifications initiate, regulate, propagate and terminate a wide
variety of processes in cells, and in particular, ubiquitylation targets substrate proteins for …
variety of processes in cells, and in particular, ubiquitylation targets substrate proteins for …