Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system
represent two instruments of basic and translational research, which both allow to acquire …

Despite the ability of combination antiretroviral therapy (cART) to increase the life
expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs …

Human immunodeficiency virus (HIV) infection can be controlled by anti-retroviral therapy.
Suppressing viral replication relies on life-long medication, but anti-retroviral therapy is not …

Of the 37.9 million individuals infected with human immunodeficiency virus type 1 (HIV-1),
approximately 50% exhibit HIV-associated neurocognitive disorders (HAND). We and others …

Neurodegeneration is a hallmark of many diseases and disorders of the central nervous
system (CNS). High levels of neuroinflammation are often associated with irreparable …

The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated
by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production …

Abstract The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …

Macrophage is a very promising cell type for cancer immunotherapy, yet it is difficult to
obtain enough functional macrophages for clinical cell therapy. Herein, we descibe a …

The evolution of drug-resistant viral strains and anatomical and cellular reservoirs of HIV
pose significant clinical challenges to antiretroviral therapy. CCR5 is a coreceptor critical for …