Autophagy is a powerful tool that host cells use to defend against viral infection. Double-
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …

Mitochondria have a central role in regulating a range of cellular activities and host
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …

Members of the Flaviviridae virus family comprise a large group of enveloped viruses with a
single-strand RNA genome of positive polarity. Several genera belong to this family …

Infections in the first year of life are common and often severe. The newborn host
demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of …

Diffuse white matter disease associated with small vessel disease and dementia is prevalent
in the elderly. The biological mechanisms, however, remain elusive. Using pericyte-deficient …

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …

Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for
the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to …