Poly (glycerol)-based biomedical nanodevices constructed by functional programming on inorganic nanoparticles for cancer nanomedicine

N Komatsu - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Nanomedicine is promising to improve conventional cancer medicine by
making diagnosis and therapy more accurate and more effective in a more personalized …

The Transition from Metal-Based to Metal-Free Contrast Agents for T1 Magnetic Resonance Imaging Enhancement

OU Akakuru, MZ Iqbal, M Saeed, C Liu… - Bioconjugate …, 2019 - ACS Publications
Magnetic resonance imaging (MRI) has received significant attention as the noninvasive
diagnostic technique for complex diseases. Image-guided therapeutic strategy for diseases …

A polymeric 1 H/19 F dual-modal MRI contrast agent with a snowman-like Janus nanostructure

Z Duan, J Han, Y Liu, X Zhao, B Wang… - Journal of Materials …, 2024 - pubs.rsc.org
Magnetic resonance imaging (MRI) has emerged as a pivotal tool in contemporary medical
diagnostics, offering non-invasive and high-resolution visualization of internal structures …

Enhancing the efficacy of metal‐free MRI contrast agents via conjugating nitroxides onto PEGylated cross‐linked poly (carboxylate ester)

S Guo, X Wang, Y Dai, X Dai, Z Li, Q Luo… - Advanced …, 2020 - Wiley Online Library
Herein, two water‐soluble PROXYL‐based magnetic resonance imaging (MRI)
macromolecular organic contrast agents (mORCAs) are designed and synthesized: linear …

Innovative Perspectives on Metal Free Contrast Agents for MRI: Enhancing Imaging Efficacy, and AI-Driven Future Diagnostics

A Wahab, M Suhail, T Eggers, K Shehzad, OU Akakuru… - Acta Biomaterialia, 2025 - Elsevier
Abstract The US Food and Drug Administration (FDA) has issued a boxed warning and
mandated additional safety measures for all gadolinium-based contrast agents (GBCAs) …

TEMPO-conjugated tobacco mosaic virus as a magnetic resonance imaging contrast agent for detection of superoxide production in the inflamed liver

JL Lumata, LM Hagge, MA Gaspar, I Trashi… - Journal of Materials …, 2024 - pubs.rsc.org
Superoxide, an anionic dioxygen molecule, plays a crucial role in redox regulation within the
body but is implicated in various pathological conditions when produced excessively. Efforts …

A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence

S Guo, X Wang, Z Li, D Pan, Y Dai, Y Ye, X Tian… - Journal of …, 2021 - Springer
Background Macromoleculization of nitroxides has been an effective strategy to improve low
relaxivities and poor in vivo stability, however, nitroxides-based metal-free magnetic …

New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance

NA Chumakova, EN Golubeva, SV Kuzin, TA Ivanova… - Polymers, 2020 - mdpi.com
A novel approach based on convolution of the electron paramagnetic resonance (EPR)
spectra was used for quantitative study of the release kinetics of paramagnetic dopants from …

Nitroxide radical contrast agents for safe magnetic resonance imaging: progress, challenges, and perspectives

X Yuan, H Yu, L Wang, MA Uddin, C Ouyang - Materials Horizons, 2025 - pubs.rsc.org
Magnetic resonance imaging (MRI) is considered one of the most valuable diagnostic
technologies in the 21st century. To enhance the image contrast of anatomical features, MRI …

Magnetic Mixed Micelles Composed of a Non-Ionic Surfactant and Nitroxide Radicals Containing a d-Glucosamine Unit: Preparation, Stability, and Biomedical …

K Nagura, Y Takemoto, F Yoshino, A Bogdanov… - Pharmaceutics, 2019 - mdpi.com
Metal-free magnetic mixed micelles (mean diameter:< 20 nm) were prepared by mixing the
biocompatible non-ionic surfactant Tween 80 and the non-toxic, hydrophobic pyrrolidine-N …