Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …

High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being
applied to gain insights into the adaptive immune response in healthy individuals and in …

The vertebrate adaptive immune system modifies the genome of individual B cells to encode
antibodies that bind particular antigens. In most mammals, antibodies are composed of …

Comprehensive knowledge of immunoglobulin genetics is required to advance our
understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are …

Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding
sequence for certain cell surface receptors is at the origin of immune system diversity. This …

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has
been associated with aging, disease susceptibility, and differential response to infection and …

In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …

The immunoglobulin (IG) loci consist of repeated and highly homologous sets of genes of
different types, variable (V), diversity (D) and junction (J), that rearrange in developing B …

The indigenous populations of the South Pacific experience a high burden of rheumatic
heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD …

Antibodies (Abs) produced by immunoglobulin (IG) genes are the most diverse proteins
expressed in humans. While part of this diversity is generated by recombination during B …