Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Natural macromolecules, such as proteins and nucleic acids, display various complex
functionalities in biological systems. These functionalities depend on the macromolecular …

The extraordinary rate accelerations and control of reactivity exhibited by enzymes have
long inspired efforts to develop synthetic catalysts. Foldamers, which are oligomers with a …

Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …

The α-helix is pre-eminent in structural biology and widely exploited in protein folding,
design and engineering. Although other helical peptide conformations do exist near to the α …

Amphiphilic self-assembling peptides are widely used in tissue and cell engineering,
antimicrobials, drug-delivery systems and other biomedical fields due to their good …

Biomimetic membranes incorporating artificial water channels (AWCs) are being developed
for industrial water purification. Designing AWCs to achieve high water permeation with salt …

The rational design of α-helix–mimicking peptidomimetics provides a streamlined approach
to discover potent inhibitors for protein− protein interactions (PPIs). However, designing cell …

Substantial progress has been made toward the development of metal-free catalysts of
enantioselective transformations, yet the discovery of organic catalysts effective at low …

Different classes of foldamers, which are synthetic oligomers that adopt well-defined
conformations in solution, have been the subject of extensive studies devoted to the …