Scavenger receptors (SRs) are a 'superfamily'of membrane-bound receptors that were
initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is …

The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity
conveys a gradual but independent risk of progression of CKD that seems irrespective of the …

Animal models link ectopic lipid accumulation to renal dysfunction, but whether this process
occurs in the human kidney is uncertain. To this end, we investigated whether altered renal …

CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a
significant role in the progression of cancer, as well as the course of atherosclerosis, renal …

Albuminuria is commonly used as a marker of kidney disease progression, but some
evidence suggests that albuminuria also contributes to disease progression by inducing …

Altered lipid metabolism characterizes proteinuria and chronic kidney diseases. While it is
thought that dyslipidemia is a consequence of kidney disease, a large body of clinical and …

Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to
a living environment of various stresses and pathological stimuli, podocytes are prone to …

In the past 15 years, major advances have been made in understanding the role of lipids in
podocyte biology. First, susceptibility to focal segmental glomerulosclerosis (FSGS) and …

Background: Podocytes, functionally specialized and terminally differentiated glomerular
visceral epithelial cells, are critical for maintaining the structure and function of the …

Diabetic nephropathy (DN) represents a major public health cost. Tight glycemic and blood
pressure control can dramatically slow, but not stop, the progression of the disease, and a …