The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Abstract The Zebrafish Model Organism Database (ZFIN; https://zfin. org) is the central
resource for genetic, genomic, and phenotypic data for zebrafish (Danio rerio) research …

Highlights•More than 60 zebrafish chemical screens have been reported since 2000.•We
summarize the current practices in design of high-throughput zebrafish screens.•We …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

Visualizing the cell cycle behavior of individual cells within living organisms can facilitate the
understanding of developmental processes such as pattern formation, morphogenesis, cell …

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation
of biological processes. Compound toxicities, chemical alterations by metabolism …

Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit
fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental …

Whole-organism chemical screening can circumvent bottlenecks that impede drug
discovery. However, in vivo screens have not attained throughput capacities possible with in …