A rather complex and pleiotropic endogenous signalling system was discovered in the late
1990s, starting from studies on the mechanism of action of Δ9-tetrahydrocannabinol, the …

Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …

Commensal bacteria are believed to have important roles in human health. The
mechanisms by which they affect mammalian physiology remain poorly understood, but …

Surgical resection is the main curative option for gastrointestinal cancers. The extent of
cancer resection is commonly assessed during surgery by pathologic evaluation of (frozen …

The trillions of bacteria that make up the human microbiome are believed to encode
functions that are important to human health; however, little is known about the specific …

Thirty years ago, the discovery of a cannabinoid (CB) receptor that interacts with the
psychoactive compound in Cannabis led to the identification of anandamide, an …

The importance of peroxisomes in lipid metabolism is now well established and
peroxisomes contain approximately 60 enzymes involved in these lipid metabolic pathways …

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A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-
arachidonoyl ethanolamine (Anandamide), and called N-acyl amides have emerged as a …

The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and
some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic …