Mammalian G proteins and their cell type specific functions
N Wettschureck, S Offermanns - Physiological reviews, 2005 - journals.physiology.org
Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …
[HTML][HTML] 2013 European thyroid association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors
Hyperthyroidism is mainly due to autoimmune thyroid disorders or toxic goiter, and very
rarely to the presence of thyrotropin (TSH)-secreting pituitary adenomas (TSHomas). These …
rarely to the presence of thyrotropin (TSH)-secreting pituitary adenomas (TSHomas). These …
Endocrine manifestations of stimulatory G protein α-subunit mutations and the role of genomic imprinting
LS Weinstein, S Yu, DR Warner, J Liu - Endocrine reviews, 2001 - academic.oup.com
The heterotrimeric G protein Gs couples hormone receptors (as well as other receptors) to
the effector enzyme adenylyl cyclase and is therefore required for hormone-stimulated …
the effector enzyme adenylyl cyclase and is therefore required for hormone-stimulated …
The cytogenesis and pathogenesis of pituitary adenomas
PITUITARY tumors are common neoplasms that exhibit a wide range of biological behavior,
in terms of hormonal and proliferative activities. Their hormonal activity is usually reflective of …
in terms of hormonal and proliferative activities. Their hormonal activity is usually reflective of …
Thyrotropin-secreting pituitary tumors: diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the National Institutes of Health
F Brucker-Davis, EH Oldfield… - The Journal of …, 1999 - academic.oup.com
We report a large series of 25 patients with TSH-secreting tumors (23 macroadenomas)
followed at the NIH. Hyperthyroid symptoms were severe in 14 patients, mild in 8, and …
followed at the NIH. Hyperthyroid symptoms were severe in 14 patients, mild in 8, and …
TSH-secreting adenomas
P Beck-Peccoz, L Persani, D Mannavola… - Best Practice & Research …, 2009 - Elsevier
Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism
and account for less than 2% of all pituitary adenomas. In the last years, the diagnosis has …
and account for less than 2% of all pituitary adenomas. In the last years, the diagnosis has …
Thyrotropin-secreting pituitary adenomas: epidemiology, diagnosis, and management
FG Amlashi, NA Tritos - Endocrine, 2016 - Springer
Inappropriate secretion of TSH was first described in 1960 in a patient with evidence of
hyperthyroidism and expanded sella on imaging. It was later found that a type of pituitary …
hyperthyroidism and expanded sella on imaging. It was later found that a type of pituitary …
Effects of G-protein mutations on skin color
CD Van Raamsdonk, KR Fitch, H Fuchs… - Nature …, 2004 - nature.com
A new class of dominant dark skin (Dsk) mutations discovered in a screen of∼ 30,000 mice
is caused by increased dermal melanin. We identified three of four such mutations as …
is caused by increased dermal melanin. We identified three of four such mutations as …
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas
CL Ronchi, E Peverelli, S Herterich… - European journal of …, 2016 - academic.oup.com
Context Alterations in the cAMP signaling pathway are common in hormonally active
endocrine tumors. Somatic mutations at GNAS are causative in 30–40% of GH-secreting …
endocrine tumors. Somatic mutations at GNAS are causative in 30–40% of GH-secreting …