[HTML][HTML] The making of the Drosophila mushroom body
S Lin - Frontiers in Physiology, 2023 - frontiersin.org
The mushroom body (MB) is a computational center in the Drosophila brain. The intricate
neural circuits of the mushroom body enable it to store associative memories and process …
neural circuits of the mushroom body enable it to store associative memories and process …
Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes‐Jensen syndrome
The widespread availability of genetic testing for those with neurodevelopmental disorders
has highlighted the importance of many genes necessary for the proper development and …
has highlighted the importance of many genes necessary for the proper development and …
[HTML][HTML] A circular RNA Edis-Relish-castor axis regulates neuronal development in Drosophila
Circular RNAs (circRNAs) are a new group of noncoding/regulatory RNAs that are
particularly abundant in the nervous system, however, their physiological functions are …
particularly abundant in the nervous system, however, their physiological functions are …
[HTML][HTML] Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
Background KDM5 family proteins are multi-domain regulators of transcription that when
dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate …
dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate …
[HTML][HTML] Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition
characterized by altered brain connectivity and function. In this study, we employed …
characterized by altered brain connectivity and function. In this study, we employed …
[HTML][HTML] Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types
Notch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates,
yet how it specifies different fates in different contexts remains elusive. In our accompanying …
yet how it specifies different fates in different contexts remains elusive. In our accompanying …
Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease
H Liu, Y Xie, X Wang, MI Abboud, C Ma… - Alzheimer's & …, 2022 - Wiley Online Library
Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients
with cardiovascular disease are prone to Alzheimer's disease (AD). 2‐Oxoglutarate and …
with cardiovascular disease are prone to Alzheimer's disease (AD). 2‐Oxoglutarate and …
KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons
Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals
with intellectual disability (ID). To understand the link between KDM5 and ID, we …
with intellectual disability (ID). To understand the link between KDM5 and ID, we …
[HTML][HTML] WNT signalling control by KDM5C during development affects cognition
V Karwacki-Neisius, A Jang, E Cukuroglu, A Tai, A Jiao… - Nature, 2024 - nature.com
Although KDM5C is one of the most frequently mutated genes in X-linked intellectual
disability, the exact mechanisms that lead to cognitive impairment remain unknown. Here we …
disability, the exact mechanisms that lead to cognitive impairment remain unknown. Here we …
Soma‐to‐germline transformation in chromatin‐linked neurodevelopmental disorders?
KM Bonefas, S Iwase - The FEBS journal, 2022 - Wiley Online Library
Mutations in numerous chromatin regulators cause neurodevelopmental disorders (NDDs)
with unknown mechanisms. Understandably, most research has focused on how chromatin …
with unknown mechanisms. Understandably, most research has focused on how chromatin …