[HTML][HTML] Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
A Sanchez, P Ortega, R Sakhtemani… - Nature …, 2024 - nature.com
Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of
mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially …
mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially …
APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability
Mutation signatures associated with apolipoprotein B mRNA editing catalytic polypeptide-
like 3A/B (APOBEC3A/B) cytidine deaminases are prevalent across cancers, implying their …
like 3A/B (APOBEC3A/B) cytidine deaminases are prevalent across cancers, implying their …
The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences
GW Brown - bioRxiv, 2024 - biorxiv.org
APOBEC proteins are cytidine deaminases that restrict the replication of viruses and
transposable elements. Several members of the APOBEC3 family, APOBEC3A, APOBEC3B …
transposable elements. Several members of the APOBEC3 family, APOBEC3A, APOBEC3B …