During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Proper formation of the mammalian heart requires precise spatiotemporal transcriptional
regulation of gene programs in cardiomyocytes. Sophisticated regulatory networks have …

The c-fos gene (also known as Fos) is induced by a broad range of stimuli and is a reliable
marker for neural activity. Here we demonstrate that multiple enhancers surrounding the c …

Major histocompatibility complex class I (MHCI) molecules negatively regulate cortical
connections and are implicated in neurodevelopmental disorders, including autism …

Hypertension is a globally prevalent pathological condition and an underlying risk factor for
the development of cardiac hypertrophy leading to heart failure. Myocyte enhancer factor 2 …

Objective: Excessive apoptosis plays an important role in the progression of intervertebral
disc degeneration. However, the effect of autophagy, another type of programmed cell …

Development of cardiovascular disease induced by excessive Gq protein–coupled receptor
agonist stimulation depends on signaling networks involving multiple matrix …

Our understanding of the molecular processes which regulate cardiac function has grown
immeasurably in recent years. Even with the advent of β-blockers, angiotensin inhibitors and …

The mammalian target of rapamycin (mTOR), an evolutionarily conserved serine–threonine
protein kinase, belongs to the phosphoinositide 3-kinase (PI3K)-related kinase family, which …

During the postnatal period, mammalian cardiomyocytes undergo numerous maturational
changes associated with increased cardiac function and output, including hypertrophic …