Inflammation is an essential immune response for the maintenance of tissue homeostasis. In
a general sense, acute and chronic inflammation are different types of adaptive response …

Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

Although obesity is known to be critical for cancer development, how obesity negatively
impacts antitumor immune responses remains largely unknown. Here, we show that …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …

Overweight and obesity are major risk factors for diabetes, cardiovascular disease, and lung
disease. These diseases are the most commonly reported health conditions that predispose …

Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue
mass and is closely associated with the development of insulin resistance in peripheral …

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …

Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. As a hormone, leptin regulates food intake and …

Adipose tissue is an active endocrine organ that secretes various humoral factors
(adipokines), and its shift to production of proinflammatory cytokines in obesity likely …