Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

Abstract Methyltransferase-like 3 (METTL3) functions as an RNA methyltransferase that
controls the modification of N (6)-methyladenosine (m6A) to influence the biosynthesis …

Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble
polarity complexes function to specify and maintain apical and basolateral membrane …

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

The STK11/LKB1 gene codes for liver kinase B1 (STK11/LKB1), a highly conserved
serine/threonine kinase involved in many energy-related cellular processes. The canonical …

Objective and design We investigated the expressions of lncRNA MEG3 and PTEN in
ovarian cancer tissues and their effects on cell proliferation, cycle and apoptosis of ovarian …

Background Characterization of tumor-related genetic alterations is promising for the
screening of new predictive markers in non-small cell lung cancer (NSCLC). Aim of the study …