How introns enhance gene expression
O Shaul - The international journal of biochemistry & cell biology, 2017 - Elsevier
In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …
gene expression without functioning as a binding site for transcription factors. This …
The exon junction complex as a node of post-transcriptional networks
HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions
L Ayadi, A Galvanin, F Pichot, V Marchand… - Biochimica et Biophysica …, 2019 - Elsevier
Methylation of riboses at 2′-OH group is one of the most common RNA modifications found
in number of cellular RNAs from almost any species which belong to all three life domains …
in number of cellular RNAs from almost any species which belong to all three life domains …
[HTML][HTML] The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus
In addition to sculpting eukaryotic transcripts by removing introns, pre-mRNA splicing greatly
impacts protein composition of the emerging mRNP. The exon junction complex (EJC) …
impacts protein composition of the emerging mRNP. The exon junction complex (EJC) …
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex
J Saulière, V Murigneux, Z Wang… - Nature structural & …, 2012 - nature.com
The exon junction complex (EJC) is a central effector of the fate of mRNAs, linking nuclear
processing to mRNA transport, translation and surveillance. However, little is known about …
processing to mRNA transport, translation and surveillance. However, little is known about …
Exon junction complex shapes the transcriptome by repressing recursive splicing
Recursive splicing (RS) starts by defining an" RS-exon," which is then spliced to the
preceding exon, thus creating a recursive 5′ splice site (RS-5ss). Previous studies focused …
preceding exon, thus creating a recursive 5′ splice site (RS-5ss). Previous studies focused …
The exon junction complex: a lifelong guardian of mRNA fate
During messenger RNA (mRNA) biogenesis and processing in the nucleus, many proteins
are imprinted on mRNAs assembling them into messenger ribonucleoproteins (mRNPs) …
are imprinted on mRNAs assembling them into messenger ribonucleoproteins (mRNPs) …
Imaging of endogenous messenger RNA splice variants in living cells reveals nuclear retention of transcripts inaccessible to nonsense-mediated decay in Arabidopsis
Alternative splicing (AS) is an important regulatory process that leads to the creation of
multiple RNA transcripts from a single gene. Alternative transcripts often carry premature …
multiple RNA transcripts from a single gene. Alternative transcripts often carry premature …
Insights into the design and interpretation of iCLIP experiments
Background Ultraviolet (UV) crosslinking and immunoprecipitation (CLIP) identifies the sites
on RNAs that are in direct contact with RNA-binding proteins (RBPs). Several variants of …
on RNAs that are in direct contact with RNA-binding proteins (RBPs). Several variants of …
[HTML][HTML] CWC22 connects pre-mRNA splicing and exon junction complex assembly
The exon junction complex (EJC) is a key regulator of posttranscriptional mRNA fate and
binds to mRNA during splicing. Although the composition of EJCs is well understood, the …
binds to mRNA during splicing. Although the composition of EJCs is well understood, the …