▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

Adhesive interactions play critical roles in directing the migration, proliferation, and
differentiation of cells; aberrations in such interactions can lead to pathological disorders …

Integrin receptor binding to extracellular matrix proteins generates intracellular signals via
enhanced tyrosine phosphorylation events that are important for cell growth, survival, and …

Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin
cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is …

Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral
membrane proteins involved in the transmission of signals from the extracellular …

The organization of the actin cytoskeleton can be regulated by soluble factors that trigger
signal transduction events involving the Rho family of GTPases. Since adhesive interactions …

Integrins are the major cell surface receptors for extracellular matrix molecules, which play
critical roles in a variety of biological processes. Focal adhesion kinase has recently been …

The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton
and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse …

The interaction of cells with extracellular matrix proteins plays a critical role in a variety of
biological processes. Recent studies suggest that cell-matrix interactions mediated by …